Rational library design by functional CDR resampling
نویسندگان
چکیده
منابع مشابه
A Rational Design for a Weighted Finite-State Transducer Library
1 Overview We describe the design principles and main algorithms for an object-oriented library for weighted nite-state transducers, which are nite automata in which each transition has an output and a weight as well as the more familiar input. The main goal of the library is to provide algorithms and representations for all the symbolic processing components (language models, dictionaries, aco...
متن کاملRational principles of compound selection for combinatorial library design.
It is practically impossible in a short period of time to synthesize and test all compounds in any large exhaustive chemical library. We discuss rational approaches to selecting representative subsets of virtual libraries that help direct experimental synthetic efforts for both targeted and diverse library design. For targeted library design, we consider principles based on the similarity to le...
متن کاملRational design of a biomimetic cell penetrating peptide library.
Cell penetrating peptides have demonstrated potential to facilitate the cellular delivery of therapeutic molecules. Here we develop a set of 50 cell penetrating peptide based formulations with potential to deliver small interfering RNAs intercellularly. The transfection efficacy of siRNA containing lipid-like nanoparticles decorated with different peptides was evaluated both in vitro and in viv...
متن کاملThe Design of a Functional Image Library
We report on experience implementing a functional image library designed for use in an introductory programming course. Designing the library revealed subtle aspects of image manipulation, and led to some interesting design decisions. Our new library improves on the earlier Racket library by adding rotation, mirroring, curves, new pen shapes, some new polygonal shapes, as well as having a signi...
متن کاملAssessment of Multidimensional Functional Neuroimaging Data Model by Statistical Resampling
Artificially generated functional magnetic resonance imaging (fMRI) data drawn from a block-based visual stimulation paradigm were analyzed by the stochastic neuromorphic extended BS Infomax algorithm [1] implementing spatial independent component analysis (ICA) [2]. Variance estimate based on bootstrap resampling [3] was employed as model selection criterion and reliability assessment of ICA d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: New Biotechnology
سال: 2018
ISSN: 1871-6784
DOI: 10.1016/j.nbt.2017.12.005